The blog goes multimedia: with their film “What is NLRP3 and why do we care?” four PhD students from the Institute of Innate Immunity (Bonn) feature what their research is about. The research group around Prof. Eicke Latz wants to understand the cellular and molecular mechanisms behind diseases like atherosclerosis, gout or Alzheimer´s disease. In all of these diseases the protein NLRP3 (NACHT, LRR and PYD domains-containing protein 3) plays the cad and mediates detrimental inflammatory processes.
Further reading:
Crystal Formation in Inflammation
Danger signaling in atherosclerosis
Activation and regulation of the inflammasomes
Authors: Alena Grebe, Andrea Stutz, Florian Hoss and Juan F. Rodríguez Alcázar
Pingback: Bo&MeRanG – One PhD, Two Hemispheres | ImmunosensationBlog
Pingback: Platelets in the immune spotlight | ImmunosensationBlog