Tag Archives: CTLA-4

Immune Checkpoint Blockade: A milestone on the way to cure cancer

For a scientist, one of the most exciting things to happen is when basic principles established in laboratory models lead to new therapeutic approaches for humans. Most recently, the understanding of several checkpoints in T cell self-tolerance, infection and transplantation led to the development of immune checkpoint blockade to treat cancer. The use of drugs blocking specific checkpoints, such as Programmed Death 1 (PD-1) and … Continue reading Immune Checkpoint Blockade: A milestone on the way to cure cancer »