Within their publication “Cytosolic RNA:DNA hybrids activate the cGAS – STING axis“ (EMBO Journal 33, 2937-46 (2014)) Mankan et al. showed that hybrids of RNA and DNA are able to activate the cytosolic DNA sensor cGAS and thus induce a type I Interferon response. We interviewed Arun Mankan, who is a Postdoc at the Institute of Molecular Medicine, about his work on RNA:DNA hybrids.   Arun, … Continue reading Recognizing the invaders – recognition of hybrids by the innate immune system »